1760 S. BRENTWOOD BLVD., ST. LOUIS, MO 63144

FAQ - NAD+ Antiaging Therapy

What are some of the benefits of NAD+ Infusion?

Benefits of IV infusion of NAD+ with essential nutrients and amino acids, include increased energy, enhanced mood, improved sleep, decreased stress and anxiety, PTSD and depression, increased immunity, hydration, and improved exercise recovery. NAD strengthens hair, nails and skin while slowing the aging process. It is also an effective natural treatment for many chronic Illnesses:  CFS, Fibromyalgia, Alzheimer’s disease, Neurodegenerative Diseases like CTE (Chronic traumatic Encephalopathy), Chemo brain, MS  and Parkinson's disease. Above all it is a natural detox agent for alcoholism, opioid and Benzodiazepine Dependence. NAD+ is described as a “systemic advance in antiaging medicine

What is NAD+?

    • NAD stands for Nicotinamide adenine dinucleotide
  • NAD+ is a coenzyme of Niacin (Vitamin B3) that exists naturally in every cell. Niacin exists as nicotinic acid and nicotinamide. NAD takes part in over 100 metabolic functions in the cells. Its main function is energy production, important for normal functioning and well being.
      • NAD+ is also an essential component of the citric acid cycle (or Krebs cycle), a cellular process that produces energy for literally every cell and organ in the body.
      • For  energy production it reacts with O2 in mitochondria to produce ATP. Thus it enables the transfer of energy from the foods we eat to vital cell functions
      • NAD+ is also an essential cofactor of key enzymes responsible for longevity called sirtuins - SIRT1 and SIRT3 - that are intimately involved in longevity through their control of gene expression.(SiRT enzymes are activated in calorie restriction also and they work in prolonging lifespan by increasing NAD). Resveratrol and pterostilbene (more potent than resveratrol) also act by stimulating SIRT1 and SIRT3. SIRT enzymes appear to switch off genes that promote aging such as those that cause inflammation, fat synthesis and storage, and stabilization of blood sugar levels.
  • Normal aging is accompanied by a noticeable increase in fatigue and loss of motivation. The tiredness we outwardly feel reflects inward impairment of cellular functions critical to sustaining life - mainly due to lack of NAD.
    • It is continuously transformed from NAD to NADH and back in the metabolic process in mitochondria. The ratio of NAD+ / NADH regulates the activity of various enzymes involved in different metabolic pathways.
    • It is a powerful antioxidant in the body
    • NAD levels decline with age.

    What does NAD+ do?

    • Replicates, protects and repairs cells
    • Enhances production of neurotransmitters, thus improving memory, concentration and mood
    • Efficiently utilize nutrients to produce the energy the cells need to function optimally.
    • Detoxification - removing waste especially in the brain that interferes with neurotransmitters.
    • Increases NO (Nitric oxide) production - improves blood flow and blood pressure.
    • Improves vascular endothelial integrity,
    • Reverses insulin resistance and quickly establishes blood glucose regulation.
    • It is a powerful antioxidant anti inflammatory agent.
    • The brain uses 10 times more NAD for energy
    • It is protective for the cells. NAD has important neuroprotective function.
    • NAD boosts metabolism and may help to lose weight.
    • Prevents decaying of mitochondria which is a key factor in aging.

    What are the effects of NAD+ Deficiency?

    About 10% of the population suffer from irreversible chronic NED ( NAD Energy Deficiency). It is genetic due to maternal mitochondrial deletions or mutations. The decline in NAD from any cause can result in:

  • Neurotransmitter Deficiency - Memory impairment, lack of focus and concentration
      • Reduction in SIRT1 and SIRT3 leading to acceleration of aging process.
      • Mitochondrial dysfunction and eventual cellular death.
  • Chronic fatigue.
  • Weak immune system - infections, cancer
  • Alcohol and drug addiction
  • Muscle weakness and pain - fatty deposition in muscle tissue.
    • Increased fat storage in liver and adipose tissue
    • Headache, insomnia
    • Lack of ambition, apathy
    • Mood and anxiety disorders
    • Headache, insomnia

    What is Anti aging Treatment

    We provide weekly NAD infusion as an aide to slow down the aging process and restore energy and well being.

    • NAD fights aging  by restoring youthful function of basic life sustaining processes in every single cell
    • NAD is described as a major advance in “systemic anti-aging medicine”
    • NAD is necessary for cellular regeneration.
    • NAD turns off genes that are responsible for aging.- silences genes for proteins that accelerate aging (through Sirtuins)
    • NAD has an important role in DNA repair and telomere maintenance
    • Protection of brain cells and is described as a novel neurotransmitter.
    • Important Cell signalling function
    • Turns on enzymes (Sirtuins) that slows aging
    • Restores mitochondrial decay.and dysfunction.
    • Mitigates oxidative stress.
    • Anti inflammatory - Activates enzymes to prevent and correct DNA damage

    What are some of theother therapeutic Indications for NAD+?

    1. For reducing anxiety and depression, chronic or acute stress and PTSD
    2. Chronic Illnesses:  CFS, Fibromyalgia,Neurodegenerative Diseases, Parkinson's disease, Chronic Traumatic Encephalopathy (CTE),  Chemobrain, Alzheimer’s Disease.

     


    References:

    1. Gomes AP et al: Declining NAD+ induces a Pseudohypoxic State disrupting nuclear mitochondrial commuinication during aging; Cell. 2013 Dec 19; 155(7): 1624-38. doi: 10.1016/j.cell.2013.11.037.

    2. Imai et al:NAD+ and Sirtuins in aging and disease. Trends in Cell Biology24.8 (2014): 464-471   

    3 Mach, John, et al. “The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+ (H).” Nutrients 2.3 (2010): 319-329.
    Ann Neurol. 2017 Dec 28. doi: 10.1002/ana.25127. [Epub ahead of print]

    4. Rocha MC et al: Pathological mechanisms underlyingsingle large scale mitochondrial DNA deletions; Ann Neurol 2017 dec 28; doi: 10.1002 ana.25127

    5. Srivastava, S: Emerging therapeutic roles for NAD+metabolism in mitochondrial and age-related disorders:Clinical and Translational Medicine 20165:25 July 2016

    6. Shetty, Pavan K., Francesca Galeffi, and Dennis A. Turner. “Nicotinamide pre-treatment ameliorates NAD (H) hyperoxidation and improves neuronal function after severe hypoxia.” Neurobiology of disease 62 (2014): 469-478.

    7. Verdin, Eric. “NAD+ in aging, metabolism, and neurodegeneration.” Science 350.6265 (2015): 1208-1213.

    8. Imal,S, Guarente L: NAD+ and Sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29.  24360282